CORDIS Project
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This project investigates the physical mechanisms behind DNA damage response, focusing on how cells form biomolecular condensates and regulate the cell cycle after DNA damage. By combining theoretical models and experimental methods, it aims to enhance our understanding of the interplay between phase separation and osc…
DNA damage response is a crucial function in living organisms, essential for maintaining genomic integrity.
Two key processes prevent damage from propagating through generations: 1) DNA repair and 2) regulation of the cell cycle.
Recent discoveries reveal that following DNA double-strand breaks, cells form biomolecular condensates at the site of damage through liquid-liquid phase separation.
Another hallmark of the response is the initiation of oscillatory p53 concentration leading to cell cycle…
KOBENHAVNS UNIVERSITET
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