CORDIS Project
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This project investigates how the nonsense-mediated decay pathway regulates human herpes simplex virus 1 (HSV-1) infections in neurons. By understanding the virus-host interactions, the research aims to identify new therapeutic targets to combat HSV-1-related diseases.
Virus infections cause a major healthcare burden worldwide.
The neurotropic human herpes simplex virus 1 (HSV-1) establishes life-long latent infection in neurons, from which it frequently reactivates to disseminate within the population.
Clinical complications caused by HSV-1 infections range from mild (herpes labialis) to sight- (keratitis) and even life-threatening diseases (encephalitis).
Prevention and treatment of HSV-1 infections are considered a top priority by the WHO.
However, developm…
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
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