CORDIS Project
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This project explores the role of specific blood stem cells in cancer progression, particularly their transformation into supportive cells for tumors. By understanding how these cells contribute to tumor growth and metastasis, the research aims to identify new strategies for cancer treatment.
The limited success of cancer therapy especially in advanced metastatic disease warrants a reassessment, especially given our limited understanding of the nature of cancer cells and the factors that allow them to proliferate and metastasise.
Stromal cells of the tumour microenvironment, including fibroblasts, endothelial, immune, adipose and mesenchymal cells, significantly affect cancer cell characteristics and tumour fate; however, their sometimes dichotomous function in high- and low-aggressi…
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