CORDIS Project
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This project seeks to develop methods for large-scale measurement of protein interactions under mechanical stress, focusing on catch bonds. By linking mechanical stability to DNA sequencing, it aims to engineer new proteins with specific properties for applications in biomaterials and cell receptors.
Mechanical forces that steer protein interactions and folding play pivotal roles in biology.
They shape cellular fate, and are critical factors in both pathogen adhesion and immune response.
Catch bonds, atypical interfaces that increase their bound lifetime under mechanical force, play a central role in these processes.
At present, we have no model nor datasets large enough to predict if an interaction is a catch bond from its structure without doing experiments, let alone design new catch bond…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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