CORDIS Project
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This research focuses on identifying inhibitors that disrupt the interaction between RAD51 and BRCA2, aiming to enhance cancer treatment by overcoming resistance to therapies like radiotherapy and chemotherapy. The project employs a novel approach for discovering modulators of protein-protein interactions, which could…
The proposed research aims at discovering inhibitors of protein-protein interaction (PPI) between RAD51 and BRCA2 as a promising treatment of cancer, in particular to reverse the resistance of cancer cells to radiotherapy and cytotoxic chemotherapy.
The pharmacophore guided DOS approach developed in this project has the potential to be a general method for rational discovery of PPI modulators.
The researcher will acquire novel technologies and develop new skills in both scientific and management…
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