CORDIS Project
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This research aims to explore the CRISPR-Cas immune system's response to complex communities of mobile genetic elements. By studying the co-evolution of these systems, the project seeks to enhance understanding of microbial defense mechanisms and their applications in industries like dairy and phage therapy.
CRISPR-Cas is one of several distinct bacterial defence mechanisms that provide immunity against viruses (phages) and other mobile genetic elements (MGEs; e.g. plasmids).
My research aims at understanding how CRISPR-Cas-mediated immunity is affected by the complexity of MGE communities.
Using evolution assays and deep sequencing techniques I aim to study (i) the evolution of CRISPR-Cas-mediated immunity in a complex MGE community (i.e. multiple phages and plasmids), and (ii) determine the associ…
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