CORDIS Project
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This project aims to enhance our understanding of bacteriophages, which can target and kill antibiotic-resistant bacteria. By investigating the structure and dynamics of phage infection processes, the research seeks to improve phage therapy applications for treating bacterial infections.
Phages have the potential to be used in therapy because they can infect and kill pathogenic bacteria, including those resistant to antibiotics.
Although phages are simple, details of their life cycle remain unknown.
To start the infection, phages bind to and eject their genome into bacteria.
During adsorption, the phage baseplate recognises receptors in the bacterial cell wall, and therefore determines the phage specificity.
Structural knowledge of baseplates will enable the rational engineering…
Masarykova univerzita
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