CORDIS Project
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This project examines the role of the pro-inflammatory mediator PGD2 in cancer progression, particularly in ovarian cancer. It aims to understand its effects on inflammation and tumor-associated macrophages, potentially guiding therapeutic strategies.
Cancer associated inflammation is well known to contribute to tumour progression,and pro-inflammatory mediators, including cytokines and prostaglandins, can drive malignancy.
Prostaglandins are generated from arachidonic acid by the action of cyclooxygenase (COX), and include PGE2 as a major pro-inflammatory mediator, and PGD2 that has anti-inflammatory activity.
While it is well known that PGE2 promotes tumourogenesis, there is little known about the role of PGD2 in cancer.
Our aim is to establ…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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