CORDIS Project
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This project investigates the role of specific proteins in the persistence of bacterial infections, focusing on the mechanisms that allow these cells to survive and recover. It employs advanced techniques to identify and validate persistence-related genes.
As a global healthcare issue, chronic and recurrent infections are often caused by multidrug tolerant persister cells, which are regulated by redundant pathways involving the almost ubiquitous alarmone (p)ppGpp.
Despite extensive studies, two major questions in the persistence field remain to be answered, 1) the extent to which (p)ppGpp is involved in persistence and 2) how persistent cells resuscitate.
To address these questions, three state-of-the-art techniques will be used in this project. F…
KOBENHAVNS UNIVERSITET
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