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PeroxyZyme focuses on developing evolved monooxygenases, known as peroxyzymes, as practical catalysts for organic chemistry. By simplifying their catalytic mechanisms to utilize hydrogen peroxide, the project aims to enable selective functionalization of non-activated carbon-hydrogen bonds, addressing a significant cha…
Chemistry is far away from being a mature science: many desirable transformations are still out of scope.
One important example is the selective (oxy)functionalisation of non-activated C-H bonds, which still represents a dream reaction of organic chemistry.
This is because balancing high reactivity (needed for the activation of inert C-H bonds) with selectivity is difficult to achieve.
Enzymes, specifically monooxygenases, are catalysts that principally solve this challenge.Monooxygenases, howev…
TECHNISCHE UNIVERSITEIT DELFT
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