CORDIS Project
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This project studies the role of peroxisomal fatty acid oxidation in endothelial cells during blood vessel formation. It aims to uncover how metabolic changes influence different types of endothelial cells involved in angiogenesis.
MAIN
GOAL:
To characterize the role of peroxisomal fatty acid oxidation (pFAO) and its relative importance in the differently active endothelial cell (EC) subtypes during blood vessel sprouting (angiogenesis).BACKGROUND &
RATIONALE:
Activation of ECs by growth factors such as VEGF induces vessel sprouting, requiring a switch from quiescent phalanx ECs to a leading tip EC and proliferating stalk ECs.
The host lab recently showed that this angiogenic switch requires a metabolic switch, with specif…
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