CORDIS Project
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This project focuses on improving bioorthogonal reactions for chemical biology and drug discovery. It specifically aims to enhance site-specific protein labeling and imaging in T-cell acute lymphoblastic leukemia using innovative reactions in aqueous conditions.
Bioorthogonal reactions have become essential tools for Chemical Biology and Drug Discovery.
Despite recent advances in the development of bioorthogonal reactions, there still exists a need for reactions with improved kinetics and selectivities.
Alkenes have been exploited in the context of site-specific protein modification and labelling, for example in cross-metathesis, photochemical 1,3-dipolar cycloaddition and tetrazine Diels-Alder cycloaddition strategies.
Pericyclic reactions are a class…
INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
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