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The PEPTIM project investigates the use of bioactive peptides derived from allergens to improve oral immunotherapy for food allergies. By studying immune responses and gut microbiota changes in murine models, the project aims to develop new strategies for inducing tolerance in individuals with food allergies.
Food allergy (FA) is a growing health issue in urbanized countries, notably affecting children, with prevalence rates of 5.7% to 16.6% in Europe due to egg and cow's milk allergies.
Western lifestyle factors and environmental exposures contribute to FA by causing inflammation and damaging epithelial barriers.
Dysbiosis, an imbalance in gut microbiota, impairs immune development and tolerance, leading to an exaggerated Th2 response and reduced RORγt+ regulatory T cells (iTregs).Current FA treatme…
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