CORDIS Project
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This project investigates how diverse populations of neural stem cells in the brain maintain their ability to generate new neurons. By combining experimental and theoretical approaches, it aims to understand the mechanisms that govern stem cell behavior over time and space, focusing on specific biological models.
Neural stem cell (NSC) populations in the vertebrate brain generate adult-born neurons for plasticity, growth, and repair.
Neurogenic and gliogenic capacity, based on long-term NSC maintenance, functionally define “stemness”.
Stemness embodies massive NSC heterogeneity at the single cell level and requires control of maintenance or differentiation decisions at the population level.
These features remain mechanistically unreconciled.
We hypothesise that spatiotemporal interactions among heterogen…
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
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Germany, Heidelberg
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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