CORDIS Project
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This research focuses on developing peptide-coated platinum nanoparticles as a targeted cancer treatment. By controlling the formation and stabilization of these nanoparticles, the project aims to enhance their delivery to cancer cell nuclei, potentially overcoming limitations of traditional chemotherapy.
Cisplatin is an efficient chemotherapeutic drug, yet it suffers from two main disadvantages: evolving drug resistance and relatively high toxicity.
One of the latest approaches for dealing with these drawbacks has been the development of platinum nanoparticles (PtNPs) as a Pt(II) ion source.
However, this solution is far from effective, mainly due to obstacles in cancer-cell targeting and a lack of nuclear penetration.
The Wennemers group developed a combinatorial screening for the identificatio…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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