CORDIS Project
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The project focuses on designing bioavailable macrocyclic compounds to inhibit protein-protein and protein-RNA interactions. It aims to develop new therapeutic agents targeting previously undruggable biological processes through innovative peptide-based strategies.
The objective of this proposal is the elucidation of general principles for the design of bioavailable peptide-derived macrocyclic compounds and their use for the development of inhibitors of protein‒protein (PPI) and protein‒RNA interactions (PRI).
Over the last decade, drug discovery faced the problem of decreasing success rates which is mainly caused by the fact that numerous novel biological targets are reluctant to classic small molecule modulation.
In particular, that holds true for PPIs a…
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