CORDIS Project
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This project aims to develop cellular models for studying spinocerebellar ataxias (SCAs) using human induced pluripotent stem cells derived from patients. By focusing on the IP3R1 receptor and creating cerebellar organoids, the research seeks to uncover disease mechanisms and facilitate high-throughput drug screening f…
The proposed Fellowship unites a recently established patient cohort from Northern Finland with the extensive expertise of the host laboratory in investigating cerebellar disease to study spinocerebellar ataxias (SCAs), a heterogeneous group of incurable brain diseases defined by ataxia, or a loss of motor coordination.
To date, genome wide analysis studies have associated >40 genes with driving SCAs.
The vast clinical and genetic heterogeneity of the SCAs poses a significant challenge and as a…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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