CORDIS Project
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This project explores the coexistence of antibiotic-resistant and sensitive strains of Streptococcus pneumoniae. By developing complex models, it aims to understand how local adaptations to different antibiotic use can maintain this balance, potentially leading to improved treatment strategies for managing antibiotic r…
Streptococcus pneumoniae (the pneumococcus) is a bacterial species generally commensal to humans, but which occasionally causes infections responsible for the death of 800, 000 infants each year worldwide.
Multiple genotypes exhibiting resistance to antibiotics have emerged in past years.
Intriguingly, despite extensive antibiotic consumption operating strong selection for resistance, the latter remains at a stable frequency, 15% on average over the last 20 years in Europe.
This is paradoxical,…
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