CORDIS Project
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This project develops advanced biosensors, known as PCHYPERs, to enhance the imaging of hydrogen peroxide in cells using super-resolution microscopy. By improving spatial resolution, it aims to clarify the role of hydrogen peroxide in cellular signaling and metabolism.
In cells, hydrogen peroxide (H2O2) is deliberately produced and is key for a healthy cellular metabolism, and an adequate H2O2 production and delivery is required for correct cellular and tissue functions.
The majority of this H2O2 production occurs in cellular microdomains, and the signalling actions in these microdomains are restricted to a very confined area.
Most of these discoveries were made possible thanks to the use of genetically-encoded fluorescent biosensors that detect the changes i…
KATHOLIEKE UNIVERSITEIT LEUVEN
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