CORDIS Project
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This project focuses on understanding the role of non-coding mutations in cancer development. By analyzing extensive genomic data, it aims to create a comprehensive map of these mutations across various cancer types and link them to drug sensitivity and resistance.
The functional evaluation of cancer mutations has been largely restricted to the protein-coding genome, due to our lack of (i) whole-genome sequence data for cancer genomes, and (ii) knowledge about the function of the non-coding genome.
However, more recently the function of the non-coding genome has been largely annotated by the ENCODE project, where large consortia are profiling thousands of tumor and matched non-neoplastic tissue samples at the genomic, proteomic and epigenomic levels.Previo…
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United States, Cambridge
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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