CORDIS Project
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This project investigates how structured messenger RNAs interact with bacterial ribosomes during translation initiation. It focuses on the role of specific ribosomal proteins in regulating translation efficiency through mutations and global analysis.
Recent X-ray crystallographic and cryo-electron microscopy data indicate that structured mRNAs bind to the bacterial ribosome at an early step of translation initiation, to a newly characterised ribosomal site located at the “platform” of the small ribosomal subunit (the “platform-binding” site or PBS).
In a second step, the mRNAs are supposed to unfold and to migrate to the P-site to interact with the initiator tRNA.
The proposal aims at dissecting the role of ribosomal proteins situated at the…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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