CORDIS Project
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This project focuses on developing advanced inhibitors targeting intracellular proteins, specifically β-catenin, which is involved in cancer pathways. By combining innovative design techniques and phage-display maturation, it aims to create effective therapeutic options for treating cancers linked to aberrant Wnt signa…
The primary goal of this project is to integrate advanced techniques for the generation of Permeable β-hairpin-derived Inhibitors (PβhdI) of intracellular targets.
Specifically, the approach will combine site recognition and epitope discovery from de novo design with enhanced affinity achieved through phage-display maturation.
Additionally, it will improve stability and permeability via interstrand crosslinking (e.g., using bis-electrophiles or disulfides), which will also facilitate phage libra…
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