CORDIS Project
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The project aims to investigate polygenic adaptation by analyzing regulatory variants that influence gene expression across different tissues. It combines network biology with population genetics to understand how these adaptations affect human genetic diversity and disease susceptibility.
Polygenic adaptation, in which small changes in allele frequencies co-occur at multiple variants, has been proposed to be a major adaptive mechanism for complex phenotypes.
Most approaches to detect polygenic adaptation consist in combining signatures of positive selection across functionally homogenous sets of genes or variants.
However, few studies have looked at regulatory variants and none have accounted for the tissue-specificity of gene expression.Here, we propose to combine network biolog…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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