CORDIS Project
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This project investigates how non-cytolytic CD8+ T cells affect neuronal function during viral infections in the central nervous system. It aims to uncover the molecular mechanisms behind immune responses that lead to neuronal dysfunction and explore potential therapeutic interventions.
Immune responses against viruses in the central nervous system (CNS) can result in devastating outcomes.
Even non-cytolytic CD8+ T cell interactions, which purge viruses from neurons without triggering cell death, can induce permanent damage.
Yet, how this immune response irreversibly disrupts neuronal homeostasis remains unclear.Here, we will elucidate the molecular mechanisms that underlie non-cytolytic CD8+ T cell engagement with infected neurons and their consequences on neuron function in v…
UNIVERSITE DE GENEVE
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