CORDIS Project
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This project investigates how male exposure to anti-androgenic chemicals, particularly di-n-butyl phthalate, affects sperm epigenetics and influences offspring traits. By integrating animal and human studies, it aims to uncover the mechanisms of paternal epigenetic inheritance and its implications for public health.
Epigenetic inheritance may not only occur in plants and fungi but also in mammals.
While the effect of maternal lifestyle and in utero exposures is well studied, paternal epigenetic inheritance is a novel research field, especially in regard to chemical exposures.
Many environmental pollutants exhibit anti-androgenic function.
Despite the vital role of androgens in spermatogenesis, the effects of adult anti-androgen exposure on the sperm epigenome and offspring phenotype have been scarcely studi…
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