CORDIS Project
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This project investigates the biology of IgE-producing cells involved in allergic responses using genetically modified mice. It aims to understand their development, lifespan, and gene expression to inform potential new therapies for allergies.
Allergic disorders are dramatically increasing in the western world over the past several years.
Allergies are inappropriate immune responses directed against harmless environmental antigens.
Upon primary allergen encounter B cells are induced to differentiate into IgE producing plasma cells.
Mast cells and basophils are then sensitized by binding of allergen-specific IgE molecules to the high-affinity IgE receptor on the cell surface. A second allergen exposure causes cross-linking of IgE molec…
UNIVERSITATSKLINIKUM ERLANGEN
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Germany, MUNCHEN
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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