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This research investigates the role of poly(ADP)ribosylation in cancer biology, focusing on how this protein modification affects DNA repair and cell survival. The goal is to identify new therapeutic targets by understanding the mechanisms of poly(ADP)ribosylation in cancer cells.
Poly(ADP)ribosylation (pARylation) is an important post-translational modification of proteins that affects diverse biological processes such as DNA damage repair, apoptosis and transcription.
The conjugation of Poly(ADP)-ribose (pADPr) to target proteins is mediated by members of the Poly(ADP)-ribose polymerase (ARTD/PARP) protein family. ADPr can be attached either as a single moiety or as chains forming poly-ADPr polymers (pADPr).
The best-studied member of the ARTD/PARP family is ARTD1/PARP1…
INSTITUTE OF CANCER RESEARCH: THE ROYAL CANCER HOSPITAL LBG
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