CORDIS Project
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The project aims to create artificial cells that mimic the weak interactions found in living cells to improve drug screening processes. By providing a more relevant environment for testing, it seeks to enhance the accuracy of drug discovery efforts.
In the crowded cell, nonspecific interactions between biomolecules alter biochemical equilibria.
This matrix of weak nonspecific interactions is composed of hydrophobic, electrostatic, H-bonding, van der Waals, and steric interactions, and is the dark matter of biology.Inaccurate prediction of the behaviour of biomolecules inside cells hampers drug discovery:
A high throughput drug screen against a purified target protein in dilute buffer ignores the presence of these weak interactions and resul…
UNIVERSITEIT UTRECHT
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DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EV
Germany, Aachen
Type: Research institute
Activity type: Research Organisations
SME: No
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