CORDIS Project
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This research focuses on understanding the regulation of ADP-ribosylation, a key cellular modification involved in DNA damage response. By investigating a novel protein complex associated with PARP1, the project aims to uncover its role in genome maintenance using advanced genetic and biochemical techniques.
(ADP-ribosyl)ation is a dynamic post-translational modification synthesised by PARPs/ARTDs and regulates a diverse array of cellular processes, including the DNA damage response (DDR).
The last decade has significantly improved our understanding of the key enzymes involved in (ADP-ribosyl)ation and the cellular pathways they function within.
However, our understanding of how these enzymes are regulated is lacking and demands further investigation.
In this proposal I seek to redress this.I have p…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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