CORDIS Project
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The PAMinMICE project explores a novel approach to immunotherapy by developing positive allosteric modulators that enhance immune checkpoint activity. This research targets autoimmune diseases by stabilizing immune checkpoints, potentially offering new treatment options for conditions like psoriasis and rheumatoid arth…
The immune system's balance in fighting infections or cancer while avoiding autoimmune reactions is regulated by co-inhibitory and co-stimulatory immune checkpoints (ICs).
ICs are major drug targets in immunotherapy, with antibodies (Abs) blocking inhibitory ICs to fight cancer, and Abs blocking stimulatory ICs in clinical trials for autoimmune diseases.Surprisingly, but likely fuelled by the worldwide focus on IC inhibitors, the field largely ignored that ICs are genuine transmembrane receptors…
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
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