CORDIS Project
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This project investigates the assembly rules of septin complexes, which are crucial for various cellular functions, including cell division and shape maintenance. Using advanced microscopy techniques, it aims to clarify the structure and organization of septin complexes in yeast and mammalian cells, particularly in neu…
The septins are a conserved family of GTPases that interact with membranes and the cytoskeleton.
Several different septin molecules combine into nonpolar dimeric rods.
These rods are thought to assemble end-over-end into higher order structures that orchestrate complex cellular events at the interface of the cytoskeleton and the plasma membrane.
In this way, septin complexes organize the cleavage furrow in dividing cells, serve as a corset to maintain cell shape in cell motility, engulf invading…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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