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The PalmERASERs project investigates the role of palmitoylation in cancer metastasis, particularly how it influences signaling pathways in breast cancer cells. By studying the enzymes that remove this modification, the project aims to develop new therapeutic strategies targeting metastasis, especially in patients with…
Metastasis is the major cause of death in patients with cancer. A better understanding of the mechanisms driving metastasis is critical to develop more effective anti-cancer treatments.
The fatty acid palmitate has been recently identified as fuel for metastasis-promoting pathways.
However, why palmitate has such a unique pro-metastatic effect compared to other fatty acids with similar metabolic fates remains elusive.
Strikingly, I discovered that palmitoylation, a reversible post-translational…
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