CORDIS Project
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This project investigates Paget’s disease of bone, focusing on genetic and environmental factors that contribute to the disorder. It aims to identify new genetic variants and develop diagnostic tools to improve early detection and treatment strategies.
Paget’s disease of bone (PDB) is a common skeletal disorder in people of European descent characterised by abnormal bone remodeling which disrupts normal bone structure causing pain, deformity, nerve compression syndromes and fractures.
The causes of PDB are incompletely understood.
Genetic factors play a key role and some predisposing genes been identified but many remain to be discovered as do the mechanisms by which these genes influence bone cell function.
Environmental factors also contribu…
THE UNIVERSITY OF EDINBURGH
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