CORDIS Project
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This project investigates the role of mRNA metabolism in aging using the nematode Caenorhabditis elegans as a model. It aims to uncover the cellular mechanisms that influence lifespan and stress resistance through the study of specific cytoplasmic particles.
Recently, we and others have revealed that, in the nematode Caenorhabditis elegans, reduction of protein synthesis rates in somatic cells extends lifespan.
Based on this, we postulate that the molecular factors and mechanisms that control the mRNA metabolism in post-mitotic cells are critical determinants of ageing.
This project will validate this hypothesis using C. elegans as main model system, but parallel studies in Saccharomyces cerevisiae and Drosophila melanogaster will prove the conserva…
BIOMEDICAL RESEARCH FOUNDATION, ACADEMY OF ATHENS
IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON
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