CORDIS Project
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PACK-COP investigates how specific cargo receptors influence protein secretion, a vital process for cellular function. By studying yeast and human models, the project aims to uncover the mechanisms behind the selectivity of vesicular trafficking, which is crucial for understanding diseases linked to secretion defects.
Protein secretion is an essential cellular process that delivers many diverse proteins to the extracellular environment or cell surface.
This process contributes to many aspects of cellular function, including nutrient uptake, cellular communication and tissue integrity.
Secretion starts with secretory protein biogenesis and folding in the endoplasmic reticulum (ER) followed by their export from the ER and transport to the Golgi apparatus via COPII-coated vesicles, to finally reach their final d…
UNIVERSITY OF DUNDEE
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