CORDIS Project
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The PACE project seeks to develop biological pacemaker therapies to restore heart function by regenerating the cardiac conduction system. It focuses on optimizing gene delivery methods to enhance the safety and effectiveness of these therapies for patients with bradycardia.
The problem:
Ageing and age-related diseases cause degeneration of the cardiac conduction system (CCS) that creates and conducts the electrical impulse which drives the heart beat (pacing).
The resulting slow heart rate (bradycardia) necessitates electronic pacemaker implantation in 500,000 patients yearly in Europe (direct costs of €3.4 billion).
This current state-of-the-art treatment has significant limitations (dangerous complications, reduced quality-of-life) that, stemming from its design,…
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
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