CORDIS Project
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This project investigates the genetic and molecular mechanisms behind the spread of pancreatic ductal adenocarcinoma (PDAC). By utilizing advanced models and sequencing techniques, it aims to uncover the drivers of metastasis and identify potential therapeutic targets to combat this aggressive cancer.
Metastasis is the major cause of death in pancreatic ductal adenocarcinoma (PDAC).
International sequencing efforts on >800 human primaries gave comprehensive insights into PDAC genetics.
In contrast, equivalent studies for “metastasis genetics” were not possible, largely because of a lack of metastatic tissue resources, particularly of treatment-naive ones.
Another bottleneck is the scarcity of adequate experimental models recapitulating the multi-step nature of metastasis.
As a consequence, th…
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
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