CORDIS Project
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This project investigates the role of p38 alpha MAPK signaling in cancer, focusing on how it influences cell survival, proliferation, and interactions with surrounding cells. By identifying its substrates and studying its functions in tumor initiation and progression, the research aims to enhance understanding of cance…
Cell fate decisions rely on signaling pathways that integrate external signals to coordinate specific intracellular programs.
One of these pathways leads to the activation of p38α MAPK, which plays key roles in cell responses to many types of stresses as well as chemotherapeutic agents and oncogenes.
Importantly, p38α acts in a cell context-specific and cell type-specific manner to integrate signals that affect cell proliferation, differentiation and survival.
Evidence from mouse models and huma…
FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
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