CORDIS Project
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This project investigates the molecular mechanisms of P1B-type ATPases, which are crucial for transporting heavy metals across cell membranes. By using X-ray crystallography and biochemical techniques, it aims to understand metal selectivity, binding, and energy transduction in these ion pumps, contributing to our know…
Cellular concentrations of transition metals are tightly regulated to a necessary balance to satisfy essential requirements for the activity of fundamental biochemical processes and avoid toxic levels which would impair cell survival. P1B-type ATPases are a family of membrane ion pumps which utilize the energy generated by ATP hydrolysis to drive the selective heavy metal translocation across the cellular membrane against the electrochemical gradient.
Although playing a pivotal role in regulatin…
AARHUS UNIVERSITET
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