CORDIS Project
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This project investigates how macrophages respond to low oxygen conditions, focusing on their role in diseases like cancer and ischemia. It aims to identify genetic factors that influence macrophage behavior, potentially leading to new therapeutic strategies.
Macrophages exist in distinct differentiation states.
Proangiogenic/immunosuppressive (M2-like) macrophages and antitumoral/proinflammatory (M1-like) macrophages represent two extremities of a continuum.
Because lineage-defined subsets have not been identified yet, macrophage heterogeneity is likely to reflect the plasticity of these cells in response to microenvironmental signals.
The concept that hypoxia can induce inflammation has gained general acceptance.
However, little is known on how ext…
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