CORDIS Project
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This project investigates how cells sense oxygen levels, focusing on the mechanisms behind acute oxygen sensing in arterial chemoreceptors. It aims to explore the role of mitochondria and stem cells in this process, which is crucial for understanding respiratory and cardiovascular responses to low oxygen levels.
Oxygen (O2) is essential for life on Earth.
This proposal deals with the study of the molecular mechanisms underlying acute O2 sensing by cells, a long-standing issue that is yet to be elucidated.
In recent years, the discovery of hypoxia inducible transcription factors and their regulation by the O2-dependent hydroxylases has provided a solid framework for understanding genetic responses to sustained (chronic) hypoxia.
However the mechanisms of acute O2 sensing, necessary for the activation of…
UNIVERSIDAD DE SEVILLA
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