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The project OVADEX investigates how the tumor microenvironment influences treatment resistance in ovarian cancer by focusing on serine metabolism. Using patient-derived explants, it aims to explore the interactions between cancer cells and their environment in response to various therapies.
Treatment resistance in ovarian cancer (OC) is common.
Recent efforts have identified new treatment approaches with potential to improve its management, but their therapeutic effects are limited due to treatment resistances.Tumor microenvironment (TME) is emerging as a key contributor to treatment resistance, being the metabolic cross-talk between TME and OC one of the recently proposed mechanisms.
The hosting lab has evidence that platinum-resistant OC cells have defects in serine biosynthesis…
KATHOLIEKE UNIVERSITEIT LEUVEN
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