CORDIS Project
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The OTOREG project investigates how organisms sense gravity using the axolotl as a model. It aims to understand the formation and regeneration of otoconia in the inner ear, which are crucial for balance, to develop therapeutic approaches for vestibular disorders.
Gravity deeply impacts all life on Earth.
Organisms sense its directionality and use it for orientation.
In tetrapods, the gravitational sense relies on biomineral crystals, known as otoconia, in our inner ear.
Their movement is detected by sensory cells, transduced into a neural output, and interpreted by the brain.
Deterioration of the otoconia can cause severe balance issues, contributing to diseases collectively referred to as vestibular disorders.
Yet, the processes driving both otoconia fo…
TECHNISCHE UNIVERSITAET DRESDEN
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