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The ORGANOMICS project focuses on modeling human brain development using cerebral organoids and single-cell transcriptomics. It aims to understand the cellular mechanisms behind brain malformations through advanced genetic techniques and high-throughput analysis.
Technologies to sequence single-cell transcriptomes (scRNA-seq) are revolutionizing our ability to analyze cell composition and differentiation in complex tissues.
In parallel, recent innovations allow the generation of three-dimensional tissues from stem cells that recapitulate human development.
In this proposal, we will focus on human cortex development modelled by cerebral organoids.
Our vision is to create an integrative single-cell transcriptomic platform to reconstruct cerebral organoid d…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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