CORDIS Project
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This project explores the use of novel ruthenium-based compounds as photosensitizers in photodynamic therapy for cancer treatment. The aim is to enhance selectivity and effectiveness by modifying these compounds to better target cancerous cells.
In this project, I plan to use cyclometalated Ru(II) polypyridyl complexes as novel photosensitizers (PSs) in photodynamic therapy (PDT) to fight cancer.
Such compounds are easier to synthesise than the well-known porphyrins and have a higher lipophilicity (to better cross the cell membrane) and a bathochromic shift of the absorption (to irradiate at low energies) than the usual Ru(II) polypyridyl complexes.
Furthermore, I plan to couple maleimide moieties to these complexes to directly bind cys…
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