CORDIS Project
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This project focuses on developing new organometallic compounds, specifically osmium and iridium, for cancer treatment. These compounds aim to overcome resistance and side effects associated with traditional platinum-based drugs, showing promise in targeting colorectal cancer without toxicity.
Currently the most widely used drugs for the treatment of cancer are platinum compounds, used in nearly 50% of all chemotherapeutic regimens.
However the platinums can suffer from problems of resistance, a limited spectrum of activity, and side-effects.
Hence new agents with new mechanisms of action are urgently needed.
We have discovered novel organometallic osmium and iridium compounds with more potent anticancer activity and unique mechanisms of action.
Initial work on an osmium compound has…
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