CORDIS Project
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The OrganoidAlign project aims to create a computational framework for comparing organoid models with actual tissue using single-cell transcriptomics. It focuses on developing statistical models to evaluate how well organoids replicate in vivo tissues, enhancing tissue engineering and genomics applications.
The OrganoidAlign action will develop a solid computational framework for comparative modelling of organoids in the age of single-cell transcriptomics.
It will provide direct payoffs to both, tissue engineering and single-cell genomics fields.
The overarching goal is to build a set of statistically rigorous and consistent probabilistic models for aligning a single-cell transcriptomic profile of an organoid against its in vivo tissue, for quantitatively evaluating its recapitulatory power.
During…
GENOME RESEARCH LIMITED
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