CORDIS Project
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This project seeks to understand the assembly and function of the nucleus in vertebrate cells by creating synthetic nuclei. It aims to uncover the interactions between lipids, proteins, and DNA that maintain nuclear integrity, with implications for health and disease.
Shape and function of the vertebrate nucleus depend on the choreographed interplay between lipids, proteins, and DNA to form the nuclear envelope.
Even small molecular changes, such as point mutations in the proteins of the nuclear envelope (the lamina) cause detrimental human diseases including premature aging, cancer, and heart disease.
To date, a clear, mechanistically compelling explanation for the dynamic coupling of lipids, proteins, and DNA to safeguard nuclear shape and function is still…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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