CORDIS Project
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This project focuses on understanding the fission process of yeast vacuoles, which are analogous to lysosomes. By developing experimental tools and techniques, it aims to characterize the proteins involved in vacuole fission and their interactions with fusion machinery, contributing to our knowledge of organelle dynami…
Yeast vacuoles (lysosomes) will serve as an excellent model system:
Vacuoles change copy number and size in the cell cycle and upon shifts of media; due to their large diameter (up to 5 µm) these changes can be assayed by fluorescence microscopy and are amenable to genetic screening.
Moreover, an in vitro system for vacuole fusion exists and we recently succeeded in reconstituting also cell-free vacuole fission with purified organelles.
We will first build an experimental toolkit for vacuole fi…
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