CORDIS Project
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This project investigates the role of plasmacytoid dendritic cells in modulating immune responses. By using genetically modified mouse models, the research aims to clarify how these cells influence the activation of other immune cells during inflammation.
Plasmacytoid dendritic cells (pDCs) which are professional type I IFN producing cells modulate phenotype and function of conventional dendritic cells (cDCs) triggering maturation and enhancing priming of cytotoxic T lymphocytes (CTLs).
It is widely accepted that type I IFNs offer a link between innate and adaptive immune responses, but there are contrasting data regarding their immunoregulatory effects.
It has been shown that pDC derived IFNs modulate the phenotype and function of conventional D…
INSTITUT PASTEUR
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